ࡱ> XW( / 0DTimes New Roman8*<$0<Wo 0DArialNew Roman8*<$0<Wo 0" DWingdingsRoman8*<$0<Wo 0 ` .  @n?" dd@  @@`` LDL?    C x1?@8y g46d6d00ppp@ <4!d!d 0$+<4BdBd 0$+uʚ;2Nʚ;:2___PPT9/ 0? %7Developing an Ontology for Randomised Controlled TrialsJHenry Potts & Sanjay Modgil Design-a-Trial team, University College London KJRandomised controlled trials Gold standard in clinical research Units randomly assigned to groups, in which intervention(s) are compared to a control and an outcome measured Not restricted to medicine (agricultural products, advertising, archaeological conservation)Design-a-TrialDecision support software to aid inexperienced clinicians write a protocol for a randomised controlled trial (RCT) Critiquing, pre-emption, natural language generation, ... Back-end: Prolog; user interface: Visual Basic http://www.design-a-trial.net p  An ontologyA structure to encode data about RCTs Used as basis for Design-a-Trial v.2 [Sanjay s talk] Propose as an Interlingua for other trial software6L  i HistoryEON/GLIF-2 for guidelines, not trials BreastCancerProto.pont ProtegeWin example concentrating on procedural aspects Our RCT ontology Ongoing work by Tu, Noy etc.| +$. +$)>&S Trial_Model_Entity$GLIF-2 etc. are bipartite in structure Guideline_Model_Entity (procedural) Reference_information Our ontology is tripartite add Trial_Model_Entity Allows representation of trial-level concepts Trial architecture, Outcomes, Interventions, Randomisation, ...(:.@ .@   Multiple superclasses Protg allows multiple superclasses links different levels of representation crossing Guideline_Model_Entity vs. Trial_Model_Entity divide ties Outcome_measure to an Action_Step:%%IBnC Guideline_Model_Entity changesQGLIF uses an ordinal time structure Introduce temporal referents Composite stepsRR Reference_information changesjActivity Compliance_procedure Consent_procedure Structure of Intervention_procedure Outcome_variable etc.V K K  ConclusionsCopy of (mostly) documented ontology available Aim to make it downloadable from the web site and write up for publication DaT going into commercial developmentP  ` f3|` 3f3` ___>?" dd@,?lPd@  d " @ `"  n?" dd@   @@``PV    @ ` ` p>>  ph ( @   Z?d @?R  s *?P` j  Bv2 @?PP   Z?'d @?  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